Name | Phenoxazine |
Synonyms | Phenoxazine 1H-Phenoxazine 10H-phenoxazine 10H-Phenoxazine RARECHEM FH 2C 0S92 10H-Phenoxazine (9CI) 5,6-Dibenzo-1,4-oxazine 2,3,5,6-DIBENZO-1,4-OXAZINE |
CAS | 135-67-1 |
EINECS | 205-210-8 |
InChI | InChI=1/C12H9NO/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H |
InChIKey | TZMSYXZUNZXBOL-UHFFFAOYSA-N |
Molecular Formula | C12H9NO |
Molar Mass | 183.21 |
Density | 1.1261 (rough estimate) |
Melting Point | 156-159 °C (lit.) |
Boling Point | 316.88°C (rough estimate) |
Flash Point | 122.6°C |
Water Solubility | Soluble in methanol. Insoluble in water. |
Solubility | benzene: freely soluble(lit.) |
Vapor Presure | 0.000372mmHg at 25°C |
Appearance | White to gray or beige powder |
Color | Gray to green-gray |
Merck | 14,7253 |
BRN | 143234 |
pKa | 1.80±0.20(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Sensitive | `sensitive` to air and heat |
Refractive Index | 1.5880 (estimate) |
MDL | MFCD00005014 |
Physical and Chemical Properties | Leaf patchy crystal. melting point 158~159 ℃ soluble in ethanol, benzene and other organic solvents and concentrated sulfuric acid. |
Use | For Organic synthesis |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S25 - Avoid contact with eyes. S24 - Avoid contact with skin. |
WGK Germany | 3 |
RTECS | SP7450000 |
HS Code | 29349990 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
properties | molecular formula C12H8N2. Molecular weight 180.20. Also known as diazepam. Colorless or yellowish needle-like crystals. Melting point 171 ℃. Boiling point> 360 ℃. Insoluble in water, slightly soluble in ethanol, benzene and ether, soluble in inorganic acid into yellow to red solution. |
Application | The earliest application of phenazine and its derivatives was dyes, and then it was discovered that they have biological activity and can be used as fungicides. In recent years, phenazine has been widely used in the fields of medicine, pesticides, chromophores, conductors and battery materials. 1. The dye phenazine dye Especially the intermediate of phenazine crypto-based dyes, it has been used in the industrial field for more than 100 years. The earliest used dye is called septic violet (1-Hydroxy-5-methylphenazine). 2. medicine it has been found that 5,10-N,N-dihydroxyphenazine and its related compounds have the highest anti-microbial activity, and 1-hydroxyphenazine and septic violet (the simplest derivative of phenazine) also have obvious anti-microbial activity. Phenazine derivatives can treat diseases caused by multiple drug-resistant microbial infections. Phenazine compounds include phenazine-N-oxide, especially phenazine -5, 10-dioxide, and 7,8-substituted-phenazine -5, 10-dioxide. Bacteria and viruses resistant to various drugs include emophilus spp, E coli, Enterobacter spp, Citrobacter spp, Proteus spp, Morganella spp, Shigella spp, Yersiniaspp, Salmonella spp, etc. Phenazine derivatives have excellent performance in the inhibition of glutamate toxicity. Derivatives of phenazine -5-oxide and its salts have inhibitory function on glutamate toxicity. 3. Pesticides With the adjustment of agricultural production and planting structure, the planting area of fruits and vegetables is continuously expanding. However, the wilting diseases of various crops, such as the wilting diseases of cucumbers and watermelons, the wilting diseases of muskmelon and cantaloupe, the root rot diseases of sweet peppers, and the blight diseases of vegetables, various rice, wheat and other crops, etc. Bring serious damage to production. At present, pesticides that have no specific effects on these diseases at home and abroad are available, and can only be controlled by general chemical fungicides, but they are harmful to animals and humans, and long-term use will cause resistance to crop pathogens, and pesticides remaining in the environment will also Seriously damage the ecosystem, the existing chemical fungicides are not completely effective in preventing and controlling wilting root rot and stem rot diseases of various crops. |
use | for organic synthesis |